Spectrophotometric determination of pKa values for fluorescein using activity coefficient corrections
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چکیده
منابع مشابه
Spectrophotometric determination of pKa values for fluorescein using activity coefficient corrections
The absorbance of the organic water tracer compound fluorescein is known to be pH dependent but differences between the reported pK a values make it difficult to predict these absorbance changes. A new pK a determination method, which incorporated activity corrections, was used to calculate the pK a values of fluorescein. Several published pK a values were re-evaluated and were in agreement onc...
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Alex Avdeef [1] and Samuel Yalkowsky [2] have independently studied the solubility and ionization properties of an investigational drug (NSC-639829). In the study conducted by Avdeef and coworkers, the pKa value derived from Henderson-Hasselbalch (HH) equation was 4.70, which was different from the value of 3.76 as determined experimentally by the Yasuda-Shedlovsky plot using the pKa values obt...
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ژورنال
عنوان ژورنال: Water SA
سال: 2002
ISSN: 0378-4738
DOI: 10.4314/wsa.v28i4.4912